## Abstract The human paralytic neuropathy, Miller Fisher syndrome (MFS) is associated with autoantibodies specific for disialosyl epitopes on gangliosides GQ1b, GT1a, and GD3. Since these gangliosides are enriched in synaptic membranes, anti‐ganglioside antibodies may target neuromuscular junction
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Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction
✍ Scribed by Rebecca N. Cole; Stephen W. Reddel; Othon L. Gervásio; William D. Phillips
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 426 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0364-5134
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## Abstract Anti‐GQ1b antibodies are present in the Miller Fisher syndrome (MFS), a monophasic neuropathy characterized by ataxia, areflexia, ophthalmoplegia, and sometimes cranial muscle weakness. We have previously shown, at the mouse neuromuscular junction (NMJ) ex vivo, that anti‐GQ1b antibodie