Anti-MAG and anti-SGPG antibodies in neuropathy

✍ Scribed by Leonard H. van den Berg; Arthur P. Hays; Eduardo Nobile-Orazio; Lawrence J. Kinsella; Emanuela Manfredini; Massimo Corbo; Gorazd Rosoklija; David S. Younger; Robert E. Lovelace; Werner Trojaborg; Dale E. Lange; Steven Goldstein; Joel S. Delfiner; Saud A. Sadiq; William H. Sherman; Norman Latov

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 678 KB
• Volume: 19
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/(sici)1097-4598(199605)19:5<637::aid-mus12>3.0.co;2-k

✦ Synopsis

We compared the binding of human antibodies from patients with neuropathy to the myelin-associated glycoprotein (MAG), to its cross-reactive glycolipid sulfoglucuronyl paragloboside (SGPG), and to sections of peripheral nerve. Titers were correlated with the clinical presentation and results of electrophysiological and pathological studies. Most patients had a predominantly sensory or sensorimotor demyelinating neuropathy and highly elevated antibodies to both MAG and SGPG, but 2 had highly elevated antibodies to MAG alone, and 1 to SGPG alone. Two patients had predominantly motor neuropathy and highly elevated antibodies to SGPG which reacted with MAG by Western blot but not by enzyme-linked immunosorbent assay. One patient had amyotrophic lateral sclerosis and antibodies to SGPG but not to MAG. These studies indicate that the neuropathic syndrome associated with anti-MAG or -SGPG antibodies are more heterogeneous than previously suspected, and that although most of the antibodies react with both MAG and SGPG, some may react with MAG or SGPG alone.