Anti-insulin antibodies may cause hypoglycaemia following pancreas transplantation

Hypoglycaemia induced by antibodies to i

Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child

✍ N. Rochet; S. Blanche; J. C. Carel; A. Fischer; F. L. Deist; C. Griscelli; E. Va 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 862 KB

Severe hypoglycaemia developed seven months after a bone marrow transplantation in a child with severe combined immunodeficiency. His serum exerted potent insulin-like activity: (a) it stimulated insulin receptor autophosphorylation and kinase activity in cell-free systems, this effect being additiv