𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Anti-inflammatory effects of eicosapentaenoic acid on experimental skin inflammation models

✍ Scribed by K. Danno; K. Ikai; S. Imamura

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
559 KB
Volume
285
Category
Article
ISSN
0340-3696

No coin nor oath required. For personal study only.

✦ Synopsis

Anti-inflammatory effects of eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) were examined on three models of skin inflammation induced in mice by topical application of an arachidonic acid (AA) solution, ultraviolet-B (UVB) irradiation, and contact sensitization with dinitrofluorobenzen. Ear oedema reactions induced by AA and UVB irradiation were significantly suppressed in mice fed a daily dose of 300 mg]kg EPA for 2 weeks. The contact hypersensitivity reaction was not impaired by EPA. None of the skin reactions was significantly inhibited in mice fed DHA or safflower oil. The results suggest that EPA, but not DHA, has anti-inflammatory effects on AA-and UVB-indnced acute inflammation reactions.

📜 SIMILAR VOLUMES

Anti-oxidant effects of retinoids on inf
Anti-oxidant effects of retinoids on inflammatory skin diseases
✍ A. Yoshioka; Y. Miyachi; S. Imamura; Y. Niwa 📂 Article 📅 1986 🏛 Springer-Verlag 🌐 English ⚖ 545 KB

It is well known that retinoids are effective in the treatment of various dermatological disorders. It has been reported that retinoids have inhibitory effects on the generation of superoxide (O2-) by stimulated polymorphonuclear leukocytes (PMNs). In the present study, we investigated the effects o