๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Anti-inflammatory effects of blood platelets in the rat

โœ Scribed by M. J. H. Smith; J. P. Bolam

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
418 KB
Volume
129
Category
Article
ISSN
0022-3417

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โœฆ Synopsis

A selective accumulation of blood platelets occurs at the sites of intradermal injection of zymosan and carrageenan in the rat. The inflammatory response to zymosan, assessed by the local accumulation of systemic radioactive human serum albumin, was significantly enhanced in platelet-depleted rats. Similar enhancements of the paw oedemas, caused by the subplantar injection of either carrageenan or zymosan, were also observed in thrombocytopenic animals. It is concluded that blood platelets may exert protective, i.e., anti-inflammatory, effects in some models of acute inflammation in the rat.

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โœ C. T. Eason; A. Pattison; D. D. Howells; F. W. Bonner; J. F. Martin ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 552 KB

The effect of amrinone on platelet production was differentiated from that of a known bone-marrow cytotoxic agent (cyclophosphamide) and anti-platelet serum (APS). The rate of platelet production has been observed over a 4-day period in the Gunn rat using [75Se]selenomethionine cohort labelling of p