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Anti-inflammatory effects and disposition of S- and R-flurbiprofen in the rat

โœ Scribed by B. Nuernberg; R. Knihinicki; K. Williams; G.E. Freeman; C. Dalton; P.M. Brooks; R.O. Day

Book ID
115886514
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
238 KB
Volume
183
Category
Article
ISSN
0014-2999

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Stereoselective disposition of ibuprofen
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โœ Romualda D. Knihinicki; Richard O. Day; Garry G. Graham; Kenneth M. Williams ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 655 KB

R)-2-Arylpropionates are often inverted to the pharmacologically active S-enantiomers in vivo, although there is significant interspecies variability in inversion. In order to provide a basis for determining the biochemical consequences of this unique process using rats as a model, it was important