Anti-immunoglobulin antibodies IV. Cross-reaction of anti-idiotypic antibodies specific for rabbit and murine anti-a1 allotype antibodies with Fc fragment of human immunoglobulins

✍ Scribed by Constantin A. Bona; Burt Goldberg; Dennis Metzger; Jacques Urbain; Henry G. Kunkel

• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 541 KB
• Volume: 14
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830140612

✦ Synopsis

Anti-immunoglobulin antibodies IV. Cross-reaction of anti-idiotypic antibodies specific for rabbit and murine anti-al allotype antibodies with Fc fragment of human immunoglobulins*

Anti-idiotype (Id) antibodies against anti-al rabbit allotype antibodies were produced in rabbits and mice by immunization with polyclonal rabbit anti-al allotype or with a monoclonal murine anti-al allotype antibody, respectively. These antibodies recognize an interspecies cross-reactive idiotope on anti-al allotype antibodies. However, these anti-Id antibodies also react with various subclasses of human IgG. In multiple systems, it was shown that these anti-Id antibodies interact with the Fc fragment of human IgG and, therefore, exhibit a rheumatoid factor-like activity. These results support the hypothesis that y-globulin may not be the only stimulus to clones producing rheumatoid factors and that perhaps other antibodies, especially anti-Id antibodies, also bind y-globulin secondarily.