Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells
β Scribed by Hiroto Yoshida; Misato Hashizume; Miho Suzuki; Masahiko Mihara
- Book ID
- 113588669
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 883 KB
- Volume
- 634
- Category
- Article
- ISSN
- 0014-2999
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## Abstract Interleukinβ2 (ILβ2) treatment is currently used to enhance T cellβmediated immune responses against tumors or in viral infections. At the same time, ILβ2 is essential for the peripheral homeostasis of CD4^+^CD25^+^Foxp3^+^ regulatory T cells (Treg). In our study, we show that ILβ2 is a
Percentage positive cells. -'Cells incubated in TPA (10 ng/ml) or in culture medium only at a cell concentration of 2 X lo5 celldwell and tested for marker expression at day 3. Cell recoveries were 40% and 24 % for TPA and medium incubation, respectively. -'ND, not determined.