Anti-IL-12/23: The next big thing in IBD?

Development in the cynomolgus macaque fo

Development in the cynomolgus macaque following administration of ustekinumab, a human anti-il-12/23p40 monoclonal antibody, during pregnancy and lactation

✍ Pauline L. Martin; Clifford Sachs; Noritaka Imai; Hideshi Tsusaki; Satoru Oneda; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

## Abstract **BACKGROUND:** Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of interleukin (IL) 12 and IL‐23 and inhibits their pharmacological activity. To evaluate potential effects of ustekinumab treatment during pregnancy, developmental studies were conducted in cynomol