Anti-idiotypic antibodies: preparation and identification; application to the detection of antigens of Plasmodium falciparum
β Scribed by WEISHENG ZHOU; YINGJIE LI
- Book ID
- 119837145
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 617 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0141-9838
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## Abstract In order to analyze the epitope structure of carcinoembryonic antigen (CEA) and the idiotype network system, seven antiβidiotypic monoclonal antibodies (antiβId MoAbs) were generated from a BALB/c mouse immunized with antiβCEA MoAb P1β356, which recognized a synthetic peptide P1 of CEA,
The administration of xenogenic monoclonal antibodies (MAbs) leads in many cases to a host immune response represented by the generation of antibodies that can be directed against allotypic, isotypic, and idiotypic determinants present on the xenogeneic MAb. Anti-idiotypic antibodies (Ab2s) can be d