## Abstract We have previously developed 3 monoclonal anti‐idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small‐cell lung carcinoma (SCLC)‐associated sialoglycoprotein antigen sGP~90–135~. The aim of this study
✦ LIBER ✦
Anti-idiotype responses abrogate anti-CD4–induced tolerance to a tumor-specific antigen and promote systemic tumor immunity
✍ Scribed by Ronald C. Kennedy; Michael H. Shearer; Devin B. Lowe; Cynthia A. Jumper; Maurizio Chiriva-Internati; Robert K. Bright
- Book ID
- 105966780
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 230 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0340-7004
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Dendritic cells (DCs) are potent inducers of cytotoxic T lymphocytes (CTLs) when pulsed with an antigenic peptide or tumor lysate. In this report, we have used liposomemediated gene transfer to examine the ability of plasmid DNA encoding the human melanoma-associated antigen gp100 to elicit CD8 ؉ an