Anti-human immunodeficiency virus type 1 (HIV-1) activity of Achyrocline flaccida Wein DC and Gamochaeta simplicicaulis aqueous extracts
✍ Scribed by H. Salomón; S. Pampuro; L. Cavallaro; G. García; J. Coussio; R. Campos
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 96 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
The anti-human immunodeficiency virus type-1 (HIV-1) activity of two South American plant extracts was studied in vitro. The concentrations of aqueous extracts of Achyrocline flaccida Wein DC (AF) and Gamochaeta simplicicaulis (GS) that inhibit 50% of viral production were 3 and 5 g/mL respectively. The concentrations that inhibit cellular growth were 400 and 600 g/mL. Non-virucidal activity was detected. The results indicate that the potent anti-HIV-1 activities of both AF and GS extracts might occur at an early step of viral replication on infected lymphocytes of primary origin.