Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells
โ Scribed by Hideki Nakashima; Jan Balzarini; Rudi Pauwels; Dominique Schols; Jan Desmyter; Erik De Clercq
- Book ID
- 119114915
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 861 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0166-0934
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HIV-1, the etiologic agent of human AIDS, causes cell death in host and non-host cells via HIV-1 Vpr, one of its auxiliary gene product. HIV-1 Vpr can also cause cell cycle arrest in several cell types. The cellular processes that link HIV-1 Vpr to the cell death machinery are not well characterized