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Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells

โœ Scribed by Kiyotaka Nakano; Tetsuro Orita; Junichi Nezu; Takeshi Yoshino; Iwao Ohizumi; Masamichi Sugimoto; Koh Furugaki; Yasuko Kinoshita; Takahiro Ishiguro; Takao Hamakubo; Tatsuhiko Kodama; Hiroyuki Aburatani; Hisafumi Yamada-Okabe; Masayuki Tsuchiya

Book ID
116297758
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
344 KB
Volume
378
Category
Article
ISSN
0006-291X

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Monoclonal antibodies with selectivity for human hepatoma cell lines were produced by immunizing BALB/c mice with human hepatoma cell lines, HA22T/VGH or Hep 3B, and fusing sensitized mouse spleen cells with mouse myeloma cells. Two monoclonal antibodies recognizing antigens present only on human he