We examined the effect of DNase treatment of sera with antihistone activity. In non-systemic lupus erythematosus (SLE) sera, antihistone levels remained unmodified, but a significant decrease was observed in 7 of 11 SLE sera with anti-DNA antibodies. This was accompanied in some by an increase in an
Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients
β Scribed by Bevra H. Hahn; Marissa Anderson; Elizabeth Le; Antonio La Cava
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 183 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0004-3591
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To examine autoantibodies present in patients with active systemic lupus erythematosus (SLE), sera, circulating immune comptexes (CIC), and antibodies purified on DNA-immunoadsorbent were tested by enzyme immunoassay. A panel of self-antigens, including DNA, histones (HIS), glomerular basal membrane