Anti-CD4 modifies the kinetics but not the magnitude of anti-CD3-induced interleukin 2 production in peripheral T cells

✍ Scribed by Jan-Ingvar Jönsson; Klaus Eichmann

• Book ID: 102822306
• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 582 KB
• Volume: 20
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830200731

✦ Synopsis

Anti-CD4 modifies the kinetics but not the magnitude of anti-CD3-induced interleukin 2 production in peripheral T cells

We have studied the effect of Tcell receptor (TcR) cross-linking and TcR-CD4 cross-linking on the induction of interleukin (IL) 2 and IL 2 receptor mRNA expression in peripheral Tcells. We confirm our previous results using bioassays, suggesting that CD4 is involved inTcell activation by up-regulating the expression of IL 2 receptors. Furthermore,we show that this also concerns other functional T cell genes such as IL 4 and interferon-y. In contrast, similar levels of IL 2 mRNA are found inTcells activated with anti-CD3 with and without anti-CD4 antibody, suggesting that the induction of the IL 2 gene is regulated by TcR cross-linking alone and not influences by CD4. However, anti-CD4 appears to accelerate the induction of IL 2 mRNA in the T cell populations, presumably by a more rapid adhesion of the cells to the antibody-coated surface.