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Anti-CD30 immunotoxins with native and recombinant dianthin 30

✍ Scribed by Andrea Bolognesi; Pier Luigi Tazzari; Guiseppe Legname; Fabiola Olivieri; Daniela Modena; Roberto Conte; Fiorenzo Stirpe


Book ID
105228278
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
520 KB
Volume
40
Category
Article
ISSN
0340-7004

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## Abstract CD30 is selectively expressed on the tumor cells of a variety of malignant disorders of the immune system and can therefore be used as a target for an anti‐CD30 antibody‐based immunotherapy. However, CD30 is cleaved at the cell surface by tumor necrosis factor‐α converting enzyme (TACE)