Anti-CD3 antibody-induced activated killer cells: Cytokines as the additional signals for activation of killer cells in effector phase to mediate slow lysis

Treatment of the P815 murine mastocytoma

Treatment of the P815 murine mastocytoma with cisplatin or etoposide up-regulates cell-surface Fas (CD95) expression and increases sensitivity to anti-Fas antibody-mediated cytotoxicity and to lysis by anti-CD3-activated killer-T cells

✍ Brent A. Williams; Andrew P. Makrigiannis; Jonathan Blay; David W. Hoskin 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 122 KB 👁 2 views

We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (