Anti-CD3 antibodies induce T helper function for human B cell differentiation in vitro by an interleukin 2-independent pathway

Anti-CD3-based bispecific antibody desig

Anti-CD3-based bispecific antibody designed for therapy of human B-cell malignancy can induce T-cell activation by antigen-dependent and antigen-independent mechanisms

✍ Brian K. Link; Sheri A. Kostelny; Michael S. Cole; William P. Fusselman; J. Yun 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 107 KB 👁 2 views

## Anti -CD3 ؋ anti-B-cell antigen bispecific monoclonal antibodies (bsAbs) can redirect T-cell-mediated lysis toward malignant B cells. Clinical trials with CD3-based bsAbs have shown toxicity in patients which is likely related to nonspecific T-cell activation and targeting. Our current studies