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Anti-CD3 × anti-GD2 bispecific antibody redirects T-cell cytolytic activity to neuroblastoma targets

✍ Scribed by Maxim Yankelevich; Sri Vidya Kondadasula; Archana Thakur; Steven Buck; Nai-Kong V. Cheung; Lawrence G. Lum


Book ID
112168236
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
391 KB
Volume
59
Category
Article
ISSN
1545-5009

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Immunotherapeutic strategies in neurobla
✍ Manzke, Oliver ;Russello, Orsolina ;Leenen, Christiane ;Diehl, Volker ;Bohlen, H 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

Background. The antigen GD2 is selectively expressed on the surface of neuroblastoma cells, and is detected by the monoclonal antibody BW704. In this study, we describe the antitumoral capacity of the immunotoxin BW704dgA (BW704 conjugated to deglycosylated ricin A), and of anti-CD3xanti-GD2 bispeci