Anti-cancer activity of anti-p185HER-2 ricin A chain immunotoxin on gastric cancer cells
β Scribed by Xin-Xin Zhou; Feng Ji; Jing-Li Zhao; Lin-Fang Cheng; Cheng-Fu Xu
- Book ID
- 108953712
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 851 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0815-9319
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Our previous studies have demonstrated that 7 of 10 IgG antibodies against distinct epitopes on the extracellular domain of the c-erb6-2 gene product (p185) inhibit the anchorageindependent growth of SKBr3 human breast-cancer cells that overexpress this transmembrane tyrosine kinase growth-factor re
## Abstract The monoclonal antibody (MAb) SEN3I, a mouse IgG~1~ which recognizes the clusterβ5a antigen on smallβcell lung cancer (SCLC) cells, was used to prepare a selective and potent blocked ricin immunotoxin. In a series of experiments __in__ vitro and in a SCLC xenograft model in nude mice, t