𝔖 Bobbio Scriptorium
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Anti-C5 monoclonal antibody 5G1-1 holds promise in the treatment of RA

Book ID
120866849
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2001
Weight
151 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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The human monoclonal antibody (humAb) 2F5 is a potent candidate for immunotherapy of HIV-1. The xenohybridoma derived humAb 2F5 is of IgG3 kappa isotype. Generally, IgG1 isotype has a longer half-life (␀clearance) in humans than IgG3. Therefore the isotype was switched to an IgG1 by ligation of the