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Anti-arthritic effect of methotrexate: is it really mediated by adenosine?

✍ Scribed by Sven E Andersson; Lars-Håkan Johansson; Kristina Lexmüller; Gunilla M Ekström

Book ID
114303254
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
448 KB
Volume
9
Category
Article
ISSN
0928-0987

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Adenosine mediates the antiinflammatory
Adenosine mediates the antiinflammatory effects of methotrexate as well as its toxicities
✍ Bruce N. Cronstein; M. Carmen Montesinos; Edwin Chan 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB

## Abstract Methotrexate remains the mainstay of therapy for rheumatoid arthritis yet its mechanism of action remains unclear. Recent work from our laboratory indicates that methotrexate promotes increased adenosine release from cells and tissues and that the anti‐inflammatory actions of methotrexa