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Anti-a2 Integrin Antibody Induces Secretion and Activation of 72-kDa Progelatinase by Human Fibroblasts

✍ Scribed by Yoshitaka Ishibashi; Hiromichi Ito; Yousuke Seyama; Shunichiro Kubota


Book ID
111741225
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
521 KB
Volume
51
Category
Article
ISSN
1521-6543

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Proteolytic enzymes, such as matrix metalloproteases (MMPs), play a pivotal role in cancer invasion and metastasis. Invasive human rhabdomyosarcoma cells (RD) secreted proMMP-2 (72-kDa progelatinase). We found that anti-alpha3 and -alpha2 integrin antibodies induced the activated form of MMP-2 and e