Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in Central Western Africa: A tentative hypothesis on the interaction between GPX1*2 and Hbβ*S allelic products
✍ Scribed by Giovanni Destro-Bisol; Gabriella Spedini
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 646 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0002-9483
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✦ Synopsis
Phenotype and allele frequencies for erythrocyte glutathione peroxidase (GPX1) polymorphism are reported in the Mbugu and Sango (Central African Republic), Goun (Benin), and Bamileke (Cameroon) ethnic groups. The GPX1*2 allele frequencies (from 0.012 in the Sango to 0.058 in the Bamileke) fit into the range of the data already known for the Subsaharan populations. The value of GPXl*2 for study of the genetic admixture between Negro and Pygmy populations is suggested. Three different unusual GPXl electrotypes are described. Finally, we hypothesize a n interaction between GPX1*2 and Hb beta*S allelic products occurring in the sickle cells infected by Plasmodium falciparum.