Anthraquinones and Lignans from Cassia occidentalis

✍ Scribed by Shi-Fei Li; Ying-Tong Di; Yue-Hu Wang; Cheng-Jian Tan; Xin Fang; Yu Zhang; Yong-Tang Zheng; Ling Li; Hong-Ping He; Shun-Lin Li; Xiao-Jiang Hao

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 219 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900460

✦ Synopsis

Abstract

One new anthraquinone glycoside, 6‐O‐(α‐L‐rhamnopyranosyl‐(1→6)‐β‐d‐glucopyranosyl)emodin (1), and two new sesquilignans, seslignanoccidentaliols A (2) and B (3), were isolated from the whole plant of Cassia occidentalis. The structures of the new compounds were established by means of spectroscopic methods, especially 2D‐NMR data (^1^H,^1^H‐COSY, HMQC, HMBC, and ROESY), as well as HR‐ESI‐MS analysis. One previously reported sesquilignan, erythro‐guaiacylglycerol‐β‐O‐4′‐(5′)‐methoxylariciresinol, was revised to be seslignanoccidentaliol A (2). The 6‐O‐(α‐L‐rhamnopyranosyl‐(1→6)‐β‐d‐glucopyranosyl)emodin (1) exhibited moderate anti‐HIV‐1 activity with an EC~50~ value of 2.90 μg/ml and a therapeutic‐index (TI) value of 260.