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Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms

✍ Scribed by Bug, M; Dobbelstein, M


Book ID
109972921
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
712 KB
Volume
30
Category
Article
ISSN
0950-9232

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## Abstract PPP1R13L was initially identified as a protein that binds to the NF‐κB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action. One set of experimental findings based on overexpression of PPP1R13L indicates that PPP1R13L blocks apoptosis. An