✦ LIBER ✦
Anthracyclic products from Streptomyces erythromogenes nov. sp. Biotransformation of daunomycin (Dn) by an acellular preparation and synergism between Dn and some known antibiotics
✍ Scribed by Dr. Nadia M. Abdallah; M. Devys; M. Barbier
- Book ID
- 102392533
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 326 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Abstract
The filtrate broth as well as mycelium of the new strain Streptomyces erythrochromogenes nov. sp. isolated from Saudi Arabian soil, produce the antitumor antibiotic daunomycin 1 and two anthracyclic derivatives: 7‐deoxy 13‐dihydrodaunomycinone 2 and 7‐deoxy daunomycinone 4. The biotransformation of 1 to 2 and 4 by an acellular enzyme preparation from the strain was found to be NADPH and/or NADH dependent.
Mixtures of daunomycin 1 with chloramphenicol or penicillin showed superior antimicrobial activities against Bacillus subtilis ICC strain, than the individual antibiotics.