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Antamanide antagonizes the phalloidin-induced negative inotropic effect and blocks voltage dependently the fast outward K+ current in voltage-clamped frog muscle fibres

✍ Scribed by Guy Raymond; Daniel Potreau; Christian Cognard; Werner Jahn; Theodor Wieland


Book ID
115880742
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
526 KB
Volume
138
Category
Article
ISSN
0014-2999

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The effects of tetracaine (10-50 laM) and ryanodine (0.1 -10 gM) were tested on the slow outward K + current (Iso) and the mechanical tension of isolated frog muscle fibres in a voltage-clamp device (double mannitol-gap) connected to a mechanoelectric transducer. In the concentration range tested, b