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Antagonistic actions of estradiol and tamoxifen upon forskolin-dependent meiotic arrest, intercellular coupling, and the cyclic AMP content of hamster oocyte-cumulus complexes

✍ Scribed by Racowsky, Catherine

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 932 KB
Volume: 234
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402340211

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✦ Synopsis

The effects of estradiol (E2) and the anti-Ez tamoxifen (tam) on forskolin (F)-dependent meiotic arrest in hamster oocytes were investigated. The hypotheses tested were that 1) the arresting action of F is enhanced by Ez and suppressed by tam and 2) the extent of heterologous metabolic coupling and the concomitant transfer of cumulus cell cAMP into the oocyte is increased

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✍ Racowsky, Catherine 📂 Article 📅 1985 🏛 John Wiley and Sons 🌐 English ⚖ 914 KB

Forskolin, a reversible stimulator of the catalytic subunit of adenylate cyclase, has been used to determine: 1) whether an increase in hamster cumulus cell cyclic adenosine monophosphate (CAMP) results in an elevation of intraoocyte cAMP and an accompanying increase in the maintenance of meiotic ar