The 5-HT1A and 5-HT1B receptors of serotonin play important roles as auto-and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters/ modulators in the central nervous system (CNS). To determine the precise localization of these receptors, we examined their respec
Antagonist properties of (−)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain
✍ Scribed by Renato Corradetti; Nora Laaris; Naima Hanoun; Anne-Marie Laporte; Emmanuel Le Poul; Michel Hamon; Laurence Lanfumey
- Book ID
- 110003409
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 540 KB
- Volume
- 123
- Category
- Article
- ISSN
- 0007-1188
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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met