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Antagonist properties of (−)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain

✍ Scribed by Renato Corradetti; Nora Laaris; Naima Hanoun; Anne-Marie Laporte; Emmanuel Le Poul; Michel Hamon; Laurence Lanfumey


Book ID
110003409
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
540 KB
Volume
123
Category
Article
ISSN
0007-1188

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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met