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Antagonism of α3β4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration

✍ Scribed by Stanley D Glick; Isabelle M Maisonneuve; Barbara A Kitchen; Mark W Fleck


Book ID
114014573
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
274 KB
Volume
438
Category
Article
ISSN
0014-2999

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A novel series of [3.2.1] azabicyclic bi
✍ John A. Lowe III; Shari L. DeNinno; Jotham W. Coe; Lei Zhang; Scot Mente; Raymon 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 243 KB

We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show