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Antagonism of the anticonvulsant action of phenytoin, phenobarbital and acetazolamide by 6-hydroxydopamine

โœ Scribed by R.A. Browning; R.L. Simonton


Book ID
118938623
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
494 KB
Volume
22
Category
Article
ISSN
0024-3205

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After intracisternal 6-hydroxydopamine (6-OHDA) in mice, brain noradrenaline (NA) and dopamine (DA) are diminished, although the reduction of NA is more pronounced. Intracisternal injection of 6-OHDA in desmethylimipramine (DMI)-pretreated animals strengthens the depletion of DA while NA is partly p