Antagonism of morphine by long acting narcotic antagonists

✍ Scribed by Linda A. Dykstra; D. E. McMillan; L. S. Harris

• Book ID: 104774770
• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 654 KB
• Volume: 39
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00440845

✦ Synopsis

The effects of three narcotic antagonists, diprenorphine, naltrexone, and naloxone were studied on the schedule-controlled behavior of pigeons. Naltrexone decreased the rate of responding under the FR and ~I components of a multiple fixed-interval, fixed-ratio schedule. Naltrexone and diprenorphine were equipotent in blocking the rate-decreasing effects of morphine on schedule-controlled behavior when the antagonists were given immediately before morphine, and both were more potent morphine antagonists than naloxone. Higher doses of all 3 antagonists were required to block the effects of morphine as the time between the administration of the antagonist and morphine increased. Naltrexone provided a slightly better antagonism of morphine than diprenorphine when morphine was given 2 or 6 h after the antagonist and both antagonists had a longer duration of antagonist action than naloxone.