Antagonism of intracerebrally induced nicotinic convulsions in mice: A method for measuring the central antinicotinic activity of CNS acting agents
✍ Scribed by K. S. Dixit; K. M. Dhasmana; R. C. Saxena; R. P. Kohli
- Book ID
- 104759555
- Publisher
- Springer
- Year
- 1971
- Tongue
- English
- Weight
- 308 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0033-3158
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✦ Synopsis
Intracerebral administration of nicotine in mice produces convulsions without any deaths in doses which are significantly lower than the parenteral doses,
The drug seems to act on central nicotinic receptors. The antagonism of central nicotinic convulsions was thus employed for the measurement of the central antinicotinic activity of various CNS acting agents. Chlorisondamine was found to be the most potent, and next in order were atropine and ehlorpromazine. It is suggested that the method forms a simple test for evaluating the central antinicotinie activity of various CNS acting agents.