Antagonism of apomorphine-induced yawning by SCH 23390: Evidence against the autoreceptor hypothesis

✍ Scribed by M. Morelli; R. Longoni; L. Spina; G. Chiara

• Publisher: Springer
• Year: 1986
• Tongue: English
• Weight: 244 KB
• Volume: 89
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00310640

✦ Synopsis

The ability of apomorphine to induce yawning (YWG) in normal and reserpinized rats and its interaction with SCH 23390, a potent and specific D-1 receptor antagonist, was studied. Apomorphine was more potent in inducing YWG in reserpine-pretreated as compared to control rats. SCH 23390, in low doses (0.05 mg/kg SC), was able to significantly reduce the YWG evoked by apomorphine both in control and in reserpine-pretreated rats. The results indicate that D-1 receptors contribute to YWG elicited by apomorphine and contradict the idea that this effect is mediated by DA autoreceptors.