Antagonism by thyrotropin-releasing hormone (TRH) of pentobarbital-induced hypothermia in rats with brain lesions

Failure of muscarinic blockade to antago

Failure of muscarinic blockade to antagonize analepsis induced by thyrotropin-releasing hormone and MK-771 in the rat

✍ Emily M. Santori; Dennis E. Schmidt; Peter W. Kalivas; Akira Horita 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 391 KB

In the rat, the antimuscarinics atropine and scopolamine failed to block the reduction in pentobarbital-induced sleep time produced by either thyrotropin-releasing hormone (TRH) or MK-771 (a TRH analog). Previous reports have indicated that the marked analeptic effect produced by TRH is antagonized