The present investigation provides evidence for noradrenergic involvement in the elaboration of the acoustic startle reaction. Within-subject experiments demonstrated that an amine-depleting dose of reserpine enhanced the level of the startle reaction and that this effect was reversed by the catech
Antagonism between L-dopa and apomorphine in their effects on rat behavior
✍ Scribed by L. Kh. Allikmets; A. M. Zharkovskii; É. É. Vasar
- Publisher
- Springer US
- Year
- 1977
- Tongue
- English
- Weight
- 294 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0007-4888
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Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in
Normal rats and those pretreated with reserpine or cr were given L-DOPA alone or with extracerebral decarboxylase inhibitor (Ro 4-4602). l~otility was measured at two different time intervals and the brain levels of noradrenaline (NA) and dopamine (DA) were subsequently determined. No simple correl