Antagonism between intracerebroventricularly administered N-methyl-d-aspartate and bicuculline methiodide in induction of clonic seizures in mice

✍ Scribed by I.M. Kapetanovic; C. Gennings; C.D. Torchin; H.J. Kupferberg

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 424 KB
• Volume: 5
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(90)90026-r

✦ Synopsis

N-Methyl-D-aspartate and bicuculline were administered alone or as a combination by intracerebroventricular injection to mice, and their convulsant activity was monitored. Both of these compounds elicited clonic seizures, though by different mechanisms. However, their simultaneous administration resulted in less than additive induction of clonic activity.