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Anoxia-evoked intracellular pH and Ca2+ concentration changes in cultured postnatal rat hippocampal neurons

✍ Scribed by A. Diarra; C. Sheldon; C.L. Brett; K.G. Baimbridge; J. Church

Book ID
117493077
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
317 KB
Volume
93
Category
Article
ISSN
0306-4522

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The effect of chemical anoxia (azide) in the presence of glucose on the free intracellular Ca 2Ψ‰ concentration ([Ca 2Ψ‰ ] i ) and intracellular pH (pH i ) in mouse neocortical neurons was investigated using Fura-2 and BCECF. Anoxia induced a reversible increase in [Ca 2Ψ‰ ] i which was significantly i