Anomalously Coupled Nucleosides, III. Coupling of Unprotected 2-Deoxy-D-ribose at C-3 withN6-Acyladenines as a New Route to Isomers of Adenosine

Coupling of Unprotected 2-Deoxy-D-ribose

Coupling of Unprotected 2-Deoxy-D-ribose at C-3 as a New Route to 2,3-Dideoxy-3-phthalimido-D-pentoses

✍ Motawia, Mohammed S. ;Nawwar, Galal A. M. ;Andreassen, Erik S. ;Jacobsen, Jens P 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 401 KB

Direct condensation of 2-deoxy-i>-ribose (2) with phlhalirnides using P,O,&I:O/Bu~N rcagcnt in chloroform at 40°C results in ii coupling ai C-3 of the carbohydrate moiety to give an isomeric mix1 urc d2,3-dideoxy-3-phthrlimido-~-pentoses 3-5. Acetylation of 3b -5 b using acetic anhydride in dry pyri