Anomalously coupled nucleosides, I tributylammonium phosphates in chloroform for direct coupling of 2-deoxy-D-ribose withN6-substituted adenines
✍ Scribed by Andersen, Jesper ;Pedersen, Erik B.
- Book ID
- 102366528
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 363 KB
- Volume
- 1986
- Category
- Article
- ISSN
- 0947-3440
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✦ Synopsis
Phosphorus pentoxide reacts with water and tributylamine in chloroform to give a homogeneous solution of tributylammonium phosphate, pyrophosphate, and trimetaphosphate. 3-(9-Adenyl)-2,3-dideoxy-~-threo-pentopyranoses 3 precipitate on treatment of 2-deoxy-~ribose (2) with N6-substituted adenines 1 in this solution at 40°C after 7 days.
Ungewohnlich verknupfte
Nucleoside, I. -Tributylammonium-phosphate in Chloroform zur direkten Verkniipfung von 2-Desoxy-~-ribose mit N6-substituierten Adeninen Phosphorpentoxid reagiert mit Wasser und Tributylamin in Chloroform zu einer homogenen Losung von Tributylammonium-phosphat, Pyrophosphat und Trimetaphosphat. 3-(9-Adcnyl)-2,3-didesoxy-~-threo-pentofuranosen 3 fallen kristallin an, wenn I-Desoxy-~ribose (2) mit N'-substituierten Adeninen 1 in dieser Losung 7 Tage bei 40°C umgesetzt wird.