Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri-Ortho-cresyl phosphate (TOCP)

✍ Scribed by K. F. Jensen; D. M. Lapadula; J. Knoth Anderson; N. Haykal-Coates; Dr. M. B. Abou-Donia

• Book ID: 102908490
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 949 KB
• Volume: 33
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490330311

✦ Synopsis

Previous biochemical studies demonstrated a dramatic increase in phosphorylation of cytoskeletal proteins that occurs early in organophosphorus esterinduced delayed neurotoxicity (OPIDN). In this report we present immunohistochemical evidence that there is anomalous aggregation of phosphorylated neurofilaments within central and peripheral axons following organophosphate exposure. The morphology, location, and time of appearance of these aggregations are consistent with the hypothesis that the aberrant phosphorylation of cytoskeletal elements is an antecedent to the focal axonal swelling and degeneration characteristic of OPIDN.