Anomalous eosinophil granulocytes in blood and bone marrow: a diagnostic marker for infantile GM1-gangliosidosis?

✍ Scribed by R. Gitzelmann; M. A. Spycher; S. Adank; K. Baerlocher; B. Steinmann

• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 905 KB
• Volume: 144
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00491934

✦ Synopsis

On routine smears of blood and bone marrow of four patients with GM1 gangliosidosis type I, eosinophil granulocytes were unusually pale and contained faintly stained, unevenly spaced granules some of which were larger than normal and had abnormal ultrastructural appearance. The anomaly may represent a hitherto overlooked but easily obtainable diagnostic marker.