Anomalous cell surface structure of sickle cell anemia erythrocytes as demonstrated by cell surface labeling and endo-β-galactosidase treatment
✍ Scribed by Fukuda, Minoru ;Fukuda, Michiko N. ;Hakomori, Sen-Itiroh ;Papayannopoulou, Thalia
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1981
- Tongue
- English
- Weight
- 503 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0275-3723
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✦ Synopsis
Abstract
Erythrocyte surface glycoproteins from patients with various types of sickle cell anemia have been analyzed and compared with those from normal individuals. By hemagglutination with various anti‐carbohydrate antibodies, sickle cells showed profound increase of i antigens and moderate increase of GlcNAcβ1→3Galβ1→3Glc structure, whereas antigenicity toward globosidic structure was unchanged. In parallel to these findings, erythrocytes of sickle cell patients have additional sialylatcd lactosaminoglycan in Band 3. Thus, it can be concluded that erythrocytes of sickle cell patients are characterized by an altered cell surface structure which does not appear to be due to topographical changes of cell surface membrane. It is possible that the anemia or the “stress” hematopoiesis in these patients is responsible for these changes.