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Anomalies of chromosomes 17 and 22 in giant cell fibroblastoma

✍ Scribed by Paola Dal Cin; Pietro Polito; Peter Van Eyken; Raf Sciot; Jesus M. Hernandez; Juan L. Garcia; Herman Van Den Berghe

Book ID
114136264
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
466 KB
Volume
97
Category
Article
ISSN
0165-4608

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## Abstract Giant cell fibroblastoma (GCF) is a subcutaneous mesenchymal neoplasm characterized by the chromosomal t(17;22), which results in the formation of the fusion gene __COL1A1‐PDGFB__. This same fusion gene is also seen in the supernumerary ring chromosome of dermatofibrosarcoma protuberans