Annotating Nucleic Acid-Binding Function Based on Protein Structure
✍ Scribed by Eric W. Stawiski; Lydia M. Gregoret; Yael Mandel-Gutfreund
- Book ID
- 117143212
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 1006 KB
- Volume
- 326
- Category
- Article
- ISSN
- 0022-2836
No coin nor oath required. For personal study only.
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## Abstract Cellular nucleic acid binding protein (CNBP) is a small single‐stranded nucleic acid binding protein made of seven Zn knuckles and an Arg‐Gly rich box. CNBP is strikingly conserved among vertebrates and was reported to play broad‐spectrum functions in eukaryotic cells biology. Neither i
## Abstract The function of DNA‐ and RNA‐binding proteins can be inferred from the characterization and accurate prediction of their binding interfaces. However, the main pitfall of various structure‐based methods for predicting nucleic acid binding function is that they are all limited to a relati