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Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage

✍ Scribed by Sunitha Nair; M. Prakash Hande; Lina H.K. Lim


Book ID
116335434
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
715 KB
Volume
294
Category
Article
ISSN
0304-3835

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Although oxygen is required for normal aerobic respiration, hyperoxia (95% O(2)/5% CO(2)) damages DNA, inhibits proliferation in G1, S and G2 phases of the cell cycle, and induces necrosis. The current study examines whether growth arrest in G1 protects pulmonary epithelial cells from oxidative DNA