Growth arrest in G1 protects against oxy
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Raymond C. Rancourt; Daniel D. Hayes; Patricia R. Chess; Peter C. Keng; Michael
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Article
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2002
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John Wiley and Sons
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English
β 263 KB
Although oxygen is required for normal aerobic respiration, hyperoxia (95% O(2)/5% CO(2)) damages DNA, inhibits proliferation in G1, S and G2 phases of the cell cycle, and induces necrosis. The current study examines whether growth arrest in G1 protects pulmonary epithelial cells from oxidative DNA