Annelation of the thiazole ring to 1,2,4-triazines by tandem AN—ANor SNH—SNHreactions
✍ Scribed by N. N. Mochul"skaya; A. A. Andreiko; M. I. Kodess; E. B. Vasil"eva; V. I. Filyakova; A. T. Gubaidullin; I. A. Litvinov; O. G. Sinyashin; G. G. Aleksandrov; V. N. Charushin
- Book ID
- 111607747
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 515 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1573-9171
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A new synthetic approach to condensed 1,2,4-triazines based on using the tandem A N -S N ipso and S N H -S N ipso reactions has been developed. 5-Methoxy-3-penyl-1,2,4-triazine and its N 1 -methyl quaternary salt were found to react with C,N-, C,O-and N,N'-bifunctional nucleophiles (m-phenylenediami
## Abstract Reaction of 2,4‐diaryl‐2,3‐dihydro‐1,5‐benzothiazepines 1 with a mixture of acetic anhydride and pyridine afforded 3‐acetyl‐2,3‐dihydrobenzothiazoles 2 as sole products in good yields. Stereochemistry and the hindered rotation of the amide group were studied by means of NMR spectroscopy