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Ankylosing spondylitis, HLA-B27 positivity and the need for biologic therapies

✍ Scribed by Jane Freeston; Nick Barkham; Elizabeth Hensor; Paul Emery; Alexander Fraser

Book ID
113684249
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
108 KB
Volume
74
Category
Article
ISSN
1297-319X

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## Abstract The present study was performed on 61 HLA‐B27 positive first‐degree relatives and 40 HLA‐B27 negative relatives of 20 HLA‐B27 positive probands with ankylosing spondylitis (AS). Of 24 HLA‐B27 positive relatives 45 years or older, 21% had AS and 38% sacroiliitis. The HLA‐B27 negative rel